PurposeTretinoin is given to APL patients with the goal of bringing on remission. If tolerated, this should not be considered reason to discontinue therapy. The main side effects associated with the use of tretinoin is the reddening of the skin, acne getting worse, thinning of the skin, irritation and much more. If you become pregnant while using Retin-A MICRO contact your doctor right away. 01 by weight, in gel vehicle of butylated hydroxytoluene, hydroxypropyl cellulose and alcohol denatured with how to get tretinoin without tert-butyl alcohol and brucine sulfate 90.